Australia has one of the highest rates of methamphetamine dependence in the world. While counselling is effective for many people with less severe dependence, there is no proven medication treatment for severe dependence.

Lisdexamfetamine is a stimulant of the brain and is approved in Australia for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). It is a once-daily oral medication converted to dexamphetamine in the blood.  

The aim of The LiMA Study is to test if lisdexamfetamine is effective in reducing methamphetamine use, cravings and withdrawal symptoms.

This will be a randomised double-blind placebo-controlled study which means that one group will receive lisdexamfetamine and another will receive a placebo (a medication with no active ingredients), in addition to counselling. Participants, clinicians and researchers involved in the study will not know to which group they have been allocated. The two groups will be compared and the findings will contribute to evidence for the future use of lisdexamfetamine in the treatment of methamphetamine dependence.

180 people will be recruited to The LiMA Study which will be conducted in specialist treatment centres in Sydney, Newcastle, Adelaide and Melbourne. Recruitment is now open.

“I just wanted to let you guys know your site rocks !! I’ve recently successfully completed the LIMA study at Mt Druitt hospital and I have to say it blew my mind. I’ve struggled with addiction since the age of 15  (I’m now 40). I was using about a half ball a day (1.75 grams) prior to starting the trial. For the first time in my life my usage has dropped down significantly to the point where I’m lucky to be using a gram a week.

THATS A MIRACLE IN MY EYES….. this trial has giving me something I had lost nearly 20 years ago and that is HOPE….“



For further information regarding the LiMA study contact:



Drug and Alcohol Clinical Services

028 464 820



Turning Point

0435 022 042



St Vincent’s Hospital, Darlinghurst

0436 613 342

Parramatta - Mt Druitt - Blacktown

02 8670 0200

Royal Prince Alfred - Camperdown

0455 093 221



Drug and Alcohol Clinical Services

0401 676 582


If you are in need of assistance or help, contact:


National Alcohol and Other Drug hotline

1800 250 015


Lifeline – Crisis Support and Suicide Prevention

131 114